Trypanocidal effect of aqueous and ethanolic extracts of Strychnos spinosa on white mice infected with Trypanosoma brucei brucei

The emergence of trypanocidal resistance has led to a change in the behavior and use local plants for treatment parasites. activity Strychnos spinosa aqueous ethanolic extracts on Trypanosoma brucei was evaluated during ten days treatment. Thus, smear used monitor parasitaemia mice treated with spinose by gavage at doses 250, 500, 1000 mg/kg (test groups); 10 ml/kg distilled water (negative control) 1mg/kg isometamidium chloride (positive control). results pharmacological studies potential plant showed that On day (D10) mortality rates 32 %, 39 % 62 respectively 500 extract while induced 37 56 respectively. Isometamidium highest rate 85 %. lethal were 218.07 225.79 All these justify least part this traditional medicine trypanosomiasis.
 Keywords: Ethanolic - Aqueous Trypanocidal Trypanosomes Inhibition parasitaemia.